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KMID : 0854720100300030202
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 3 p.202 ~ p.208
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Clinical Significance of Past History on the Preceding Reaction to Bee Sting and Specific IgE Antibody to Bee Venom in Patients with Bee Sting Anaphylaxis
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Kim Young-Il
Park Sang-Hun
Yoon Jee-Hee
Koh Young-Il
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Abstract
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Background: Severity of allergic reactions to bee venoms may depend on the degree of previous sting reactions. Tests for venom-specific IgE antibodies are frequently positive in patients with allergic sting reactions.
Objective: We studied the clinical significance of preceding reactions and serum-specific IgE antibodies in patients with bee sting anaphylaxis.
Method: Nine patients with bee sting anaphylaxis were included. Details in the current anaphylaxis and previous
reactions were retrospectively obtained. Venom-specific IgE antibodies were measured by using ImmunoCAP in 6 patients.
Result: Seven (78%) of 9 patients had preceding reactions. Details in the reactions were available in 5 patients who were stung by the same bee or family as the current stings. Four (80%) patients of these 5 patients had experienced only large local reactions or systemic cutaneous reactions from the preceding stings. With regard to specific IgE antibodies, 2 (33%) of the 6 patients were negative for the same venoms as in the preceding stings.
Conclusion: Bee venom-induced anaphylaxis can occur although preceding reactions are local or mild systemic ones. Tests for venom-specific IgE antibodies can be negative in patients with bee sting anaphylaxis.
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KEYWORD
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Hymenoptera, Anaphylaxis, Immunoglobulin E
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